Book , Print in English

Molecular biology : principles of genome function

Nancy L. Craig ... [et al.].

Oxford ; New York : Oxford University Press, 2010.

xli, 839 pages : colored illustrations; 28 cm.

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Related names

Craig, Nancy Lynn, 1952-

Subjects

Medical Subjects

Genre

Lehrbuch.

Summary

Contents

1. Genomes and the flow of biological information
Introduction
1.1. roots of biology
1.2. genome: a working blueprint for life
1.3. Bringing genes to life: gene expression
1.4. Cellular infrastructure and gene expression
1.5. Expression of the genome
1.6. Evolution of the genome and the tree of life Summary
2. Biological molecules
Introduction
2.1. Atoms, molecules, and chemical bonds
2.2. Life in aqueous solution
2.3. Non-covalent interactions
2.4. Nucleotides and nucleic acids
2.5. structure of DNA
2.6. Chemical properties of RNA
2.7. RNA folding and structure
2.8. RNA world and its role in the evolution of modern-day life
2.9. Fundamentals of protein structure
2.10. Protein folding
2.11. Protein folds
2.12. Sugars and carbohydrates
2.13. Lipids
2.14. Chemical modification in biological regulation
Summary
Further reading
3. chemical basis of life
Introduction
3.1. Thermodynamic rules in biological systems
3.2. Binding equilibria and kinetics
3.3. Binding processes in biology
3.4. Enzyme catalysis
3.5. Enzyme kinetics
Summary
Further reading
4. Chromosome structure and function
Introduction
4.1. Organization of chromosomes
4.2. cell cycle and chromosome dynamics
4.3. Packaging chromosomal DNA
4.4. Variation in chromatin structure
4.5. Covalent modifications of histones
4.6. Nucleosome-remodeling complexes
4.7. DNA methylation
4.8. Boundary elements separate chromatin domains
4.9. Elements required for chromosome function
4.10. centromere
4.11. telomere
4.12. Chromosome architecture in the nucleus
Summary
Further reading
5. cell cycle
Introduction
5.1. Steps in the eukaryotic cell cycle
5.2. Cyclins and cyclin-dependent kinases
5.3. Regulation of Cdk activity
5.4. Cell cycle regulation by Cdks
5.5. Regulation of proteolysis by Cdks
5.6. Checkpoints: intrinsic pathways that can halt the cell cycle
5.7. Extrinsic regulators of cell cycle progression
5.8. cell cycle and cancer
5.9. bacterial cell cycle
Summary
Further reading
6. DNA replication
Introduction
6.1. Overview of DNA replication
DNA replication: core components
6.2. DNA polymerases: structure and function
6.3. DNA polymerases: fidelity and processivity
6.4. Specialized polymerases
6.5. DNA helicases: unwinding of the double helix
6.6. sliding clamp and clamp loader
DNA replication: mechanism
6.7. Origins and initiation of DNA replication
6.8. Leading and lagging strand synthesis
6.9. replication fork
6.10. Termination of DNA replication
6.11. end-replication problem and telomerase
6.12. Chromatin replication
DNA replication: regulation
6.13. Regulation of initiation of replication in E. coli
6.14. Regulation of replication initiation in eukaryotes
Summary
Further reading
7. Chromosome segregation
Introduction
7.1. stages of mitosis
7.2. Chromosome condensation and cohesion
7.3. mitotic spindle
7.4. Prometaphase and metaphase
7.5. Anaphase: an irreversible step in chromosome segregation
7.6. completion of mitosis and cytokinesis
7.7. Meiosis: generating haploid gametes from diploid cells
7.8. Chromosome segregation in bacteria
Summary
Further reading
8. Transcription
Introduction
8.1. Overview of transcription
Transcription: core components
8.2. RNA polymerase core enzyme
Transcription: mechanism
8.3. Promoter recognition in bacteria and eukaryotes
8.4. Initiation of transcription and transition to an elongating complex
8.5. Transcription elongation
8.6. Transcription termination
Transcription: regulation
8.7. Principles of transcription regulation
8.8. DNA-binding domains in transcriptional regulator
8.9. Mechanisms for regulating transcription in bacteria
8.10. Competition between cl and Cro and the fate of bacteriophage lambda
8.11. Mechanisms for modulating eukaryotic transcription
8.12. Combinatorial regulation of eukaryotic transcription
8.13. Signaling cascades and regulation of transcription
8.14. Regulation of elongation and termination by RNA and proteins
8.15. Transcriptional silencing
Summary
Further reading
9. RNA processing
Introduction
9.1. Overview of RNA processing
9.2. tRNA and rRNA processing
9.3. tRNA and rRNA nucleotide modifications
9.4. mRNA capping and polyadenylation
9.5. RNA splicing
9.6. Eukaryotic mRNA splicing by the spliceosome
9.7. Exon definition and alternative splicing
9.8. RNA editing
9.9. Degradation of normal RNAs
9.10. Degradation of foreign and defective RNAs
9.11. RNA-binding domains in proteins
Summary
Further reading
10. Translation
Introduction
10.1. Overview of translation
Translation: core components
10.2. Transfer RNA and the genetic code
10.3. Aminoacyl-tRNA synthetases
10.4. Structure of the ribosome
Translation: mechanism
10.5. translation cycle: the ribosome in action
10.6. Protein factors critical to the translation cycle
10.7. Translation initiation (mostly in bacteria)
10.8. Translation initiation in eukaryotes
10.9. Translation elongation: decoding, peptide bond formation, and translocation
10.10. Translation termination and reinitiation
Translation: regulation
10.11. Recoding: programmed stop codon read-through and frameshifting
10.12. Antibiotics that target the ribosome
10.13. Global regulation of initiation in bacteria and eukaryotes
10.14. Regulation of initiation via the 5' UTR in bacteria and eukaryotes
10.15. Regulation of translation via the 3' UTR in eukaryotes
10.16. Viral corruption of the translational machinery
Summary
Further reading
11. Protein modification and targeting
Introduction
11.1. Chaperone-assisted protein folding
11.2. Targeting of proteins throughout the cell
11.3. Post-translational cleavage of the polypeptide chain
11.4. Lipid modification of proteins
11.5. Glycosylation of proteins
11.6. Protein phosphorylation, acetylation, and methylation
11.7. Protein oxidation, nitrosylation, and nitration
11.8. Ubiquitination and sumoylation of proteins
11.9. Protein degradation
Summary
Further reading
12. Cellular responses to DNA damage
Introduction
12.1. Types of DNA damage
12.2. Post-replication mismatch repair
12.3. Repair of DNA damage by direct reversal
12.4. Repair of DNA damage by base excision repair
12.5. Nucleotide excision repair of bulky lesions
12.6. Translesion DNA synthesis
12.7. DNA damage response
12.8. DNA damage response in bacteria
12.9. DNA damage response in eukaryotes
12.10. DNA damage and cell death in mammalian cells
Summary
Further reading
13. Repair of DNA double-strand breaks and homologous recombination
Introduction
13.1. overview of DNA double-strand break repair and homologous recombination
13.2. Double-strand break repair by non-homologous end joining
13.3. Homology-directed repair of double-strand breaks
13.4. Generation of single-stranded DNA by helicases and nucleases
13.5. mechanism of DNA strand pairing and exchange
13.6. Gene conversion through homology-directed repair
13.7. Homologous recombination
13.8. Repair of damaged replication forks by homology-directed repair
13.9. Aberrant repair and recombination and chromosome rearrangements
Summary
Further reading
14. Mobile DNA
Introduction
14.1. Transposable elements: overview
14.2. DNA-only transposons
14.3. Mechanism of DNA-only cut-and-paste transposition reactions
14.4. Mechanism of DNA-only nick-and-paste transposition reactions
14.5. Cellular domestication of a DNA cut-and-paste transposase in adaptive immunity
14.6. Retrotransposons
14.7. LTR retrotransposons
14.8. Non-LTR retrotransposons
14.9. Control of transposition
14.10. Conservative site-specific recombination: overview
14.11. CSSR conversion of DNA dimers to monomers: single-protein systems
14.12. CSSR conversion of DNA dimers to monomers: systems regulated by accessory proteins
14.13. CSSR systems that control gene expression
Summary
Further reading
15. Genomics and genetic variation
Introduction
15.1. Genome sequences and sequencing projects
15.2. Finding functions in a genome
15.3. Evolutionary forces
15.4. evolving genome
15.5. Duplication and divergence of gene function
15.6. Sequence comparisons
15.7. Phenotypic variation
15.8. Exploring evolution through genomics: examples from mammalian genomes
15.9. Human genetic diseases
Summary
Further reading
16. Tools and techniques in molecular biology
Introduction
16.1. Model organisms
16.2. Cultured cells and viruses
16.3. Cloning and amplification of DNA and RNA sequences
16.4. Genome manipulation
16.5. Detection of biological molecules
16.6. Separation and isolation of biological molecules
16.7. Identification of biological molecules
16.8. Detection of specific DNA sequences
16.9. Detection of specific RNA molecules
16.10. Detection of specific proteins --
Contents note continued: 16.11. Detection of interactions between molecules
16.12. Imaging cells and molecules
16.13. Molecular structure determination
16.14. Obtaining and analyzing a complete genome sequence
16.15. Mapping human disease genes
Summary
Online resources for genomics and model organisms.

Other information

Includes bibliographical references and index.

ISBN

9780199562060 (alk. paper)
0199562067 (alk. paper)
9780199562053 (hbk.)
0199562059
9780199587940 (instructor ed.)
0199587949 (instructor ed.)

Identifying numbers

LCCN: 2010010915
OCLC: 471822472
OCLC: 471822472

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Molecular biology : principles of genome function

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